A central challenge in the analysis of genetic variation is to provide realistic genome simulation across millions of samples. Present day coalescent simulations do not scale well, or use approximations that fail to capture important long-range linkage properties. Analysing the results of simulations also presents a substantial challenge, as current methods to store genealogies consume a great deal of space, are slow to parse and do not take advantage of shared structure in correlated trees. ...Expand abstract
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- Kelleher et al.
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- © 2016 Kelleher et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Efficient coalescent simulation and genealogical analysis for large sample sizes
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