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Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122

Abstract:

BACKGROUND AND PURPOSE: Signalling through phospholipase C (PLC) controls many cellular processes. Much information on the relevance of this important pathway has been derived from pharmacological inhibition of the enzymatic activity of PLC. We found that the most frequently employed PLC inhibitor, U73122, activates endogenous ionic currents in widely used cell lines. Given the extensive use of U73122 in research, we set out to identify these U73122-sensitive ion channels. EXPERIMENTAL APPROA...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1111/bph.13538

Authors


Leitner, MG More by this author
Behrendt, M More by this author
Dierich, M More by this author
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Publisher:
Wiley Publisher's website
Journal:
British Journal of Pharmacology Journal website
Volume:
173
Issue:
16
Pages:
2555-2569
Publication date:
2016-08-05
Acceptance date:
2016-06-15
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Pubs id:
pubs:690085
URN:
uri:47f68791-3d0a-4f13-9bc9-8b6307e7fb59
UUID:
uuid:47f68791-3d0a-4f13-9bc9-8b6307e7fb59
Local pid:
pubs:690085
Language:
English
Keywords:

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