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Sclerosing cholangitis

Abstract:

Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown etiology that leads to progressive obliterative fibrosis of the biliary tree, ultimately progressing to death from liver failure or cholangiocarcinoma. Immune-mediated factors are thought to be involved in its pathogenesis, as suggested by the presence of circulating antineutrophil cytoplasmic antibodies, mainly IgG1 and IgG3. This test is not yet useful as a diagnostic tool because sensitivity and specificity va...

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Publication status:
Published

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Authors


Martins, EB More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Journal:
CURRENT OPINION IN GASTROENTEROLOGY
Volume:
13
Issue:
5
Pages:
416-421
Publication date:
1997-09-05
DOI:
ISSN:
0267-1379
URN:
uuid:47f0c734-e572-4962-8df9-7f80dab756e2
Source identifiers:
171703
Local pid:
pubs:171703
Language:
English

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