- Abstract:
-
Duchenne muscular dystrophy and the mdx mouse myopathies reflect a lack of dystrophin in muscles. However, both contain sporadic clusters of revertant fibers (RFs) that express dystrophin. RF clusters expand in size with age in mdx mice. To test the hypothesis that the expansion of clusters is achieved through the process of muscle degeneration and regeneration, we analyzed muscles of mdx mice in which degeneration and regeneration were inhibited by the expression of micro-dystrophins or utro...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/jcs.03000
-
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- Journal:
- Journal of cell science
- Volume:
- 119
- Issue:
- Pt 13
- Pages:
- 2679-2687
- Publication date:
- 2006-07-05
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- URN:
-
uuid:47f0953b-0c19-4a4d-963e-03759fdb035b
- Source identifiers:
-
106767
- Local pid:
- pubs:106767
- Copyright date:
- 2006
Journal article
Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration.
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