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Journal article

Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration.

Abstract:

Duchenne muscular dystrophy and the mdx mouse myopathies reflect a lack of dystrophin in muscles. However, both contain sporadic clusters of revertant fibers (RFs) that express dystrophin. RF clusters expand in size with age in mdx mice. To test the hypothesis that the expansion of clusters is achieved through the process of muscle degeneration and regeneration, we analyzed muscles of mdx mice in which degeneration and regeneration were inhibited by the expression of micro-dystrophins or utro...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.03000

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
Journal of cell science
Volume:
119
Issue:
Pt 13
Pages:
2679-2687
Publication date:
2006-07-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:47f0953b-0c19-4a4d-963e-03759fdb035b
Source identifiers:
106767
Local pid:
pubs:106767

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