Journal article
Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration.
- Abstract:
-
Duchenne muscular dystrophy and the mdx mouse myopathies reflect a lack of dystrophin in muscles. However, both contain sporadic clusters of revertant fibers (RFs) that express dystrophin. RF clusters expand in size with age in mdx mice. To test the hypothesis that the expansion of clusters is achieved through the process of muscle degeneration and regeneration, we analyzed muscles of mdx mice in which degeneration and regeneration were inhibited by the expression of micro-dystrophins or utro...
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- Publication status:
- Published
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- Publisher copy:
- 10.1242/jcs.03000
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Bibliographic Details
- Journal:
- Journal of cell science
- Volume:
- 119
- Issue:
- Pt 13
- Pages:
- 2679-2687
- Publication date:
- 2006-07-01
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- Source identifiers:
-
106767
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:106767
- UUID:
-
uuid:47f0953b-0c19-4a4d-963e-03759fdb035b
- Local pid:
- pubs:106767
- Deposit date:
- 2013-11-16
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- Copyright date:
- 2006
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