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Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1.

Abstract:

Caveolin-1 (Cav-1) is an integral transmembrane protein and a critical component in interactions of integrin receptors with cytoskeleton-associated and signaling molecules. Since integrin-mediated cell adhesion generates signals conferring radiation resistance, we examined the effects of small interfering RNA-mediated knockdown of Cav-1 alone or in combination with beta1-integrin or focal adhesion kinase (FAK) on radiation survival and proliferation of pancreatic carcinoma cell lines. Irradia...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1210498

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Pilarsky, C More by this author
Grützmann, R More by this author
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Journal:
Oncogene
Volume:
26
Issue:
48
Pages:
6851-6862
Publication date:
2007-10-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:47edcc33-5fbc-4bb9-9a61-c5e83955da45
Source identifiers:
118214
Local pid:
pubs:118214

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