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Non-hydrolytic functions of acetylcholinesterase: the significance of C-terminal peptides

Abstract:
This review explores the possibility that acetylcholinesterase may play a pivotal, non-hydrolytic role in neurodegeneration. More specifically, C-terminal sequences of acetylcholinesterase may act as signalling molecules in key brain regions characteristically vulnerable to Alzheimer's, Parkinson's and motor neuron disease.
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Institute for the Future of the Mind
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Institution:
University of Oxford
Department:
Institute for the Future of the Mind
More by this author
Institution:
University of Oxford
Department:
Institute for the Future of the Mind
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Funding agency for:
Martina Zimmermann
More from this funder
Funding agency for:
Cherie E. Bond
Publisher:
Blackwell Publishing Publisher's website
Journal:
FEBS Journal Journal website
Volume:
275
Issue:
4
Pages:
604-611
Publication date:
2008-02-05
DOI:
URN:
uuid:47dd0bc4-bdc8-412c-a39f-e66f6adc6b4d
Local pid:
ora:3686

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