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Azacitidine augments expansion of regulatory T cells after allogeneic stem cell transplantation in patients with acute myeloid leukemia (AML).

Abstract:

Strategies that augment a GVL effect without increasing the risk of GVHD are required to improve the outcome after allogeneic stem cell transplantation (SCT). Azacitidine (AZA) up-regulates the expression of tumor Ags on leukemic blasts in vitro and expands the numbers of immunomodulatory T regulatory cells (Tregs) in animal models. Reasoning that AZA might selectively augment a GVL effect, we studied the immunologic sequelae of AZA administration after allogeneic SCT. Twenty-seven patients w...

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Publication status:
Published

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Authors


Goodyear, OC More by this author
Jilani, NY More by this author
Siddique, S More by this author
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Journal:
Blood
Volume:
119
Issue:
14
Pages:
3361-3369
Publication date:
2012-04-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:47d30730-6a20-4f35-bc77-17061706bec4
Source identifiers:
331050
Local pid:
pubs:331050

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