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ATP-sensitive K+ channels in human isolated pancreatic B-cells.

Abstract:

Glucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated by the closing of ATP-sensitive K+ channels in the plasma membrane as a consequence of glucose metabolism. We have identified an ATP-sensitive K+ channel in membrane patches excised from human B-cells which is similar to that found in rodent B-cells in conductance, kinetics, ATP sensitivity and its inhibition by sulphonylureas. In man, the ATP-sensitive K+ channel may also have a central role in gluco...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
FEBS letters
Volume:
215
Issue:
1
Pages:
9-12
Publication date:
1987-05-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:47d0139c-76ed-4b2c-bbe0-b21fb7054275
Source identifiers:
115045
Local pid:
pubs:115045

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