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A global profile of replicative polymerase usage.

Abstract:

Three eukaryotic DNA polymerases are essential for genome replication. Polymerase (Pol) α-primase initiates each synthesis event and is rapidly replaced by processive DNA polymerases: Polɛ replicates the leading strand, whereas Polδ performs lagging-strand synthesis. However, it is not known whether this division of labor is maintained across the whole genome or how uniform it is within single replicons. Using Schizosaccharomyces pombe, we have developed a polymerase usage sequencing (Pu-seq)...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/nsmb.2962

Authors


Daigaku, Y More by this author
Keszthelyi, A More by this author
Müller, CA More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature structural and molecular biology Journal website
Publication date:
2015-03-13
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:47c7dc0a-458e-4368-b193-49d1777dfda0
Source identifiers:
510569
Local pid:
pubs:510569

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