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Immune control and failure in HCV infection--tipping the balance.

Abstract:

Despite the development of potent antiviral drugs, HCV remains a global health problem; global eradication is a long way off. In this review, we discuss the immune response to HCV infection and particularly, the interplay between viral strategies that delay the onset of antiviral responses and host strategies that limit or even eradicate infected cells but also contribute to pathogenesis. Although HCV can disable some cellular virus-sensing machinery, IFN-stimulated antiviral genes are induce...

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Publication status:
Published

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Publisher copy:
10.1189/jlb.4ri0214-126r

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Publisher:
Federation of American Societies for Experimental Biology
Journal:
Journal of leukocyte biology
Volume:
96
Issue:
4
Pages:
535-548
Publication date:
2014-10-29
DOI:
EISSN:
1938-3673
ISSN:
0741-5400
URN:
uuid:47b8e231-c7b9-4eef-a6d3-ec25661d78f7
Source identifiers:
476277
Local pid:
pubs:476277

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