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A Multi-Antigenic Adenoviral-Vectored Vaccine Improves BCG-Induced Protection of Goats against Pulmonary Tuberculosis Infection and Prevents Disease Progression

Abstract:

The "One world, one health" initiative emphasizes the need for new strategies to control human and animal tuberculosis (TB) based on their shared interface. A good example would be the development of novel universal vaccines against Mycobacterium tuberculosis complex (MTBC) infection. This study uses the goat model, a natural TB host, to assess the protective effectiveness of a new vaccine candidate in combination with Bacillus Calmette-Guerin (BCG) vaccine. Thirtythree goat kids were divided...

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Publication status:
Published

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Authors


Perez de Val, B More by this author
Villarreal-Ramos, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Andaluz, A More by this author
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Journal:
PLOS ONE
Volume:
8
Issue:
11
Pages:
e81317-e81317
Publication date:
2013-11-21
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:479d64c3-b9f8-4142-9b59-012c316ca0f7
Source identifiers:
445262
Local pid:
pubs:445262

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