Journal article icon

Journal article

The Nrd1-Nab3-Sen1 termination complex interacts with the Ser5-phosphorylated RNA polymerase II C-terminal domain.

Abstract:

RNA polymerase II (Pol II) in Saccharomyces cerevisiae can terminate transcription via several pathways. To study how a mechanism is chosen, we analyzed recruitment of Nrd1, which cooperates with Nab3 and Sen1 to terminate small nucleolar RNAs and other short RNAs. Budding yeast contains three C-terminal domain (CTD) interaction domain (CID) proteins, which bind the CTD of the Pol II largest subunit. Rtt103 and Pcf11 act in mRNA termination, and both preferentially interact with CTD phosphory...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nsmb.1468

Authors


Journal:
Nature structural and molecular biology
Volume:
15
Issue:
8
Pages:
795-804
Publication date:
2008-08-05
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
URN:
uuid:479ba2a0-9e2c-456a-91b7-d793e8704bf7
Source identifiers:
311055
Local pid:
pubs:311055

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP