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Journal article

Common variations in the ALMS1 gene do not contribute to susceptibility to type 2 diabetes in a large white UK population.

Abstract:

AIMS/HYPOTHESIS: Alström syndrome is a rare monogenic disorder characterised by retinal dystrophy, deafness and obesity. Patients also have insulin resistance, central obesity and dyslipidaemia, thus showing similarities with type 2 diabetes. Rare mutations in the ALMS1 gene cause severe gene disruption in Alström patients; however, ALMS1 gene polymorphisms are common in the general population. The aim of our study was to determine whether common variants in ALMS1 contribute to susceptibility...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-006-0227-2

Authors


Minton, JA More by this author
Weedon, MN More by this author
Frayling, TM More by this author
Ricketts, C More by this author
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Journal:
Diabetologia
Volume:
49
Issue:
6
Pages:
1209-1213
Publication date:
2006-06-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:4798b224-ef20-41c0-a1ae-0b90541efcf4
Source identifiers:
6893
Local pid:
pubs:6893

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