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Escape of human immunodeficiency virus from immune control.

Abstract:

Cytotoxic T lymphocytes (CTL) play a crucial role in the attempt to control infection with human immunodeficiency virus (HIV). Variation in epitopes recognized by CTL is common and frequently offers potential escape routes for mutant virus. Proof of escape, however, requires demonstration of increased frequency of virus particles or provirus that carry the escape sequence. There are now several recorded examples of virus variants that escape from CTL and are then selected. Most dramatic are t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Journal:
Annual review of immunology
Volume:
15
Issue:
1
Pages:
271-296
Publication date:
1997
DOI:
EISSN:
1545-3278
ISSN:
0732-0582
URN:
uuid:479584af-0c46-4d7b-b746-639b0c1445f8
Source identifiers:
25560
Local pid:
pubs:25560

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