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Evidence-based medicine. Part 2: Randomised controlled trials

Abstract:
The modern randomised controlled trial is the most reliable inferential means of investigating treatment effects. Its development during the 20th century turned clinical medicine into a rigorous experimental science. The second in a series, this article discusses the practical challenges of conducting trials including randomisation, allocation concealment and blinding, and explains concepts such as intention to treat and equipoise. Large diabetes randomised controlled trials are used as examples.

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Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences
Role:
Author
Journal:
Diabetes and Primary Care
Volume:
13
Issue:
2
Pages:
82-87
Publication date:
2011-01-01
ISSN:
1466-8955
URN:
uuid:4780cf4a-caf2-4f77-9bf6-eeec87efcd79
Source identifiers:
199195
Local pid:
pubs:199195
Language:
English
Keywords:

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