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Primaquine for prevention of malaria in travelers.

Abstract:

An expanding risk and range of endemic malaria threatens travelers. Primaquine is an old drug recently demonstrated to offer effective prophylaxis. Clinical trials conducted in Indonesia, Kenya, and Colombia showed that a primaquine base (30 mg per day) had protective efficacy against Plasmodium falciparum and Plasmodium vivax of 85%-93%. Among 339 children (age, >8 years) and adults taking this regimen for 12-52 weeks, there was no greater risk of adverse symptomatic events among primaqui...

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Publication status:
Published

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Publisher copy:
10.1086/379714

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Fryauff, DJ More by this author
Hoffman, SL More by this author
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
37
Issue:
12
Pages:
1659-1667
Publication date:
2003-12-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:477f1cbe-805a-45c1-85a3-f0c0c1d502a1
Source identifiers:
81788
Local pid:
pubs:81788

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