Journal article

Poly-l-glutamic acid derivatives as vectors for gene therapy

Abstract:: This paper describes the synthesis and evaluation of biodegradable derivatives of poly-l-glutamic acid as suitable vectors for gene therapy. When mixed with DNA the new polymers self assemble and form polyelectrolyte complexes. The formation of the complexes and determination of their stability towards disruption by serum albumin was monitored by Ethidium bromide (EtBr) fluorescence spectroscopy. All polymers were able to form complexes and their size, determi...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Dekie, L., Toncheva, V., Dubruel, P., Schacht, E., Barrett, L., & Seymour, L. (2000). Poly-l-glutamic acid derivatives as vectors for gene therapy. Journal of Controlled Release, 65(1-2), 187–202.

MLA Style

Dekie, L., et al. “Poly-l-Glutamic Acid Derivatives as Vectors for Gene Therapy.” Journal of Controlled Release, vol. 65, no. 1-2, Elsevier, 2000, pp. 187–202.

Chicago Style

Dekie, L, V Toncheva, P Dubruel, E Schacht, L Barrett, and L Seymour. 2000. “Poly-l-Glutamic Acid Derivatives as Vectors for Gene Therapy.” Journal of Controlled Release 65 (1-2): 187–202.
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Publisher copy:: 10.1016/S0168-3659(99)00235-7

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+ Dekie, L More by this author

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+ Toncheva, V More by this author

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+ Dubruel, P More by this author

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+ Schacht, E More by this author

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+ Barrett, L More by this author

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Bibliographic Details

Publisher:: Elsevier
Journal:: Journal of Controlled Release More from this journal
Volume:: 65
Issue:: 1-2
Pages:: 187-202
Publication date:: 2000-02-25
Acceptance date:: 1999-08-23
DOI:: 10.1016/S0168-3659(99)00235-7
EISSN:: 1873-4995
ISSN:: 0168-3659

Item Description

Keywords:: Gene therapy and biodegradation

SBTMR

Poly-l-glutamic acid
Pubs id:: pubs:709412
UUID:: uuid:47467865-cff6-4328-8ac3-defe3d561420
Local pid:: pubs:709412
Source identifiers:: 709412
Deposit date:: 2017-07-27

Terms of use

Copyright holder:: Elsevier
Copyright date:: 2000
Notes:: © 2000 Published by Elsevier Science B.V. All rights reserved

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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