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Gene silencing by DNA methylation in haematological malignancies.

Abstract:

The past decade has seen an explosion of interest in the epigenetics of cancer, with an increasing understanding that this form of genomic modification plays a critical role in pathogenesis. The malignant phenotype results from a step-wise increase of both genetic abnormalities and epigenetic modifications, leading to dysregulation of critical genes controlling cell growth, differentiation and apoptosis. The methylation of CpG islands within gene promoters is a major epigenetic transcriptiona...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Wainscoat, JS More by this author
Journal:
British journal of haematology
Volume:
138
Issue:
1
Pages:
3-11
Publication date:
2007-07-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:47436170-d9e1-4eda-8106-03c39027f0fd
Source identifiers:
246232
Local pid:
pubs:246232

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