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Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction.

Abstract:

OBJECTIVE: Galectin-3 (Gal-3) is a 26-kDa lectin known to regulate many aspects of inflammatory cell behavior. We assessed the hypothesis that increased levels of Gal-3 contribute to atherosclerotic plaque progression by enhancing monocyte chemoattraction through macrophage activation. METHODS AND RESULTS: Gal-3 was found to be upregulated in unstable plaque regions of carotid endarterectomy (CEA) specimens compared with stable regions from the same patient (3.2-fold, P<0.05) at the mRNA ...

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Publication status:
Published

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Publisher copy:
10.1161/atvbaha.107.159160

Authors


Papaspyridonos, M More by this author
McNeill, E More by this author
de Bono, JP More by this author
Burnand, KG More by this author
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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
28
Issue:
3
Pages:
433-440
Publication date:
2008-03-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:473529e7-a98c-474f-a1aa-b87e6c273cd1
Source identifiers:
24844
Local pid:
pubs:24844

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