- Abstract:
-
The phosphoramidite monomer of the C-nucleoside 2'-aminoethoxy-2-amino-3-methylpyridine (AE-MAP) has been synthesized for the first time and incorporated into triplex-forming oligonucleotides (TFOs). Ultraviolet melting and DNase I footprinting studies show that AE-MAP is a potent triplex-stabilizing monomer that is selective for GC base pairs. TFOs containing AE-MAP bind with high affinity to duplexes but only weakly to single stranded DNA. In addition, AE-MAP confers high nuclease resistanc...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/chem.201102287
-
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- Journal:
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Volume:
- 17
- Issue:
- 52
- Pages:
- 14851-14856
- Publication date:
- 2011-12-05
- DOI:
- EISSN:
-
1521-3765
- ISSN:
-
0947-6539
- URN:
-
uuid:471f2e67-25d8-40fa-9006-425f587c1b3d
- Source identifiers:
-
399986
- Local pid:
- pubs:399986
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
2'-Aminoethoxy-2-amino-3-methylpyridine in triplex-forming oligonucleotides: high affinity, selectivity and resistance to enzymatic degradation.
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