Journal article
Detecting signatures of past pathogen selection on human HLA loci: are there needles in the haystack?
- Abstract:
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Human leucocyte antigens (HLAs) are responsible for the display of peptide fragments for recognition by T-cell receptors. The gene family encoding them is thus integral to human adaptive immunity, and likely to be under strong pathogen selection. Despite this, it has proved difficult to demonstrate specific examples of pathogen–HLA coevolution. Selection from multiple pathogens simultaneously could explain why the evolutionary signatures of particular pathogens on HLAs have proved elusive. He...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 431.8KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 482.3KB, Terms of use)
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- Publisher copy:
- 10.1017/S0031182017001159
Authors
Funding
+ European Research Council
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Funding agency for:
Gupta, S
Grant:
FP7/2007-2013)/ERC 268904-DIVERSITY
Bibliographic Details
- Publisher:
- Cambridge University Press
- Journal:
- Parasitology More from this journal
- Volume:
- 145
- Issue:
- 6
- Pages:
- 731-739
- Publication date:
- 2017-08-15
- Acceptance date:
- 2017-06-01
- DOI:
- EISSN:
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1469-8161
- ISSN:
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0031-1820
Item Description
- Keywords:
- Pubs id:
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pubs:723823
- UUID:
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uuid:471ebe8c-f45a-4ee6-9e22-eda949008367
- Local pid:
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pubs:723823
- Source identifiers:
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723823
- Deposit date:
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2017-08-21
Terms of use
- Copyright holder:
- Cambridge University Press
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Cambridge University Press. This is the accepted manuscript version of the article. The final version is available online from Cambridge University Press at: https://doi.org/10.1017/S0031182017001159
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