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CryoEM-based hybrid modeling approaches for structure determination.

Abstract:

Recent advances in cryo-electron microscopy (cryoEM) have dramatically improved the resolutions at which vitrified biological specimens can be studied, revealing new structural and mechanistic insights over a broad range of spatial scales. Bolstered by these advances, much effort has been directed toward the development of hybrid modeling methodologies for the construction and refinement of high-fidelity atomistic models from cryoEM data. In this brief review, we will survey the key elements ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.mib.2017.10.002

Authors


Cassidy, CK More by this author
Luthey-Schulten, Z More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Structural Biology
National Science Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Current Opinion in Microbiology Journal website
Volume:
43
Pages:
14-23
Publication date:
2017-11-04
DOI:
EISSN:
1879-0364
ISSN:
1369-5274
Pubs id:
pubs:747022
URN:
uri:471157e6-5686-4a78-80ca-f4767bc5216c
UUID:
uuid:471157e6-5686-4a78-80ca-f4767bc5216c
Local pid:
pubs:747022
Language:
English
Keywords:

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