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Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity.

Abstract:

BACKGROUND: Statins improve clinical outcome of patients with atherosclerosis, but their perioperative role in patients undergoing coronary artery bypass grafting (CABG) is unclear. We hypothesized that short-term treatment with atorvastatin before CABG would improve the redox state in saphenous vein grafts (SVGs), independently of low-density lipoprotein cholesterol (LDL)-lowering. METHODS AND RESULTS: In a randomized, double-blind controlled trial, 42 statin-naïve patients undergoing elect...

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Publication status:
Published

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Authors


Antoniades, C More by this author
Bakogiannis, C More by this author
Tousoulis, D More by this author
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Journal:
Circulation
Volume:
122
Issue:
11 Suppl
Pages:
S66-S73
Publication date:
2010-09-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:4702673d-7132-4d63-a9cc-a3ec2684387c
Source identifiers:
104901
Local pid:
pubs:104901

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