Journal article
Health-related quality of life in people with type 2 diabetes participating in the LEADER trial
- Abstract:
-
Aims To assess health‐related quality of life (HRQoL) in people with type 2 diabetes (T2D) participating in the LEADER cardiovascular outcomes trial using the five‐dimension European Quality of Life questionnaire (EQ‐5D).
Materials and methods The EQ‐5D was administered every 12 months in a subset of patients from Canada, Denmark, Germany, Ireland, Italy, Netherlands, Spain, Sweden, the United Kingdom and the United States. We compared changes in utility index scores and visual analogue scale (VAS) scores from baseline to 36 months in participants treated with liraglutide and placebo. We also assessed which complications had the greatest impact on quality of life.
Results At 36 months, less deterioration in EQ‐5D utility index score was seen in the liraglutide group (−0.058) than in the placebo group (−0.082; estimated treatment difference [ETD] 0.023, 95% confidence interval [CI] 0.004;0.043; P = 0.020). A smaller decrease in EQ‐5D VAS score was also demonstrated in the liraglutide group (−3.51) vs. the placebo group (−5.45; ETD 1.94, 95% CI 0.32;3.57; P = 0.019). The benefits of liraglutide treatment compared with placebo were driven primarily by shifts in the domains of mobility and self‐care. The most influential events contributing to poorer HRQoL were stroke, heart failure, malignant neoplasm and confirmed hypoglycaemia.
Conclusions Liraglutide demonstrated a modest but significant benefit in patient‐reported health status using the EQ‐5D, compared with placebo. This benefit may be of clinical relevance and requires further study.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 685.9KB, Terms of use)
-
- Publisher copy:
- 10.1111/dom.13547
Authors
- Publisher:
- Wiley
- Journal:
- Diabetes, Obesity and Metabolism More from this journal
- Volume:
- 21
- Issue:
- 3
- Pages:
- 525-532
- Publication date:
- 2018-10-25
- Acceptance date:
- 2018-09-23
- DOI:
- EISSN:
-
1463-1326
- ISSN:
-
1462-8902
- Pmid:
-
30260088
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:923960
- UUID:
-
uuid:4700ea1c-00e4-4116-ab51-2128be418f3c
- Local pid:
-
pubs:923960
- Source identifiers:
-
923960
- Deposit date:
-
2019-03-05
Terms of use
- Copyright holder:
- Nauck et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
If you are the owner of this record, you can report an update to it here: Report update to this record