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Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort

Abstract:

Anhedonia and amotivation are debilitating symptoms and represent unmet therapeutic needs in a range of clinical conditions. The gut-microbiome-endocannabinoid axis might represent a potential modifiable target for interventions. Based on results obtained from animal models, we tested the hypothesis that the endocannabinoid system mediates the association between gut-microbiome diversity and anhedonia/amotivation in a general population cohort. We used longitudinal data collected from 786 ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41380-021-01147-5

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Role:
Author
ORCID:
0000-0002-6309-6324
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Role:
Author
ORCID:
0000-0001-9751-5219
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Role:
Author
ORCID:
0000-0002-4910-0489
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Role:
Author
ORCID:
0000-0001-9790-0571
Publisher:
Springer Nature
Journal:
Molecular psychiatry More from this journal
Volume:
26
Issue:
11
Pages:
6269-6276
Publication date:
2021-05-17
Acceptance date:
2021-04-22
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
Pmid:
34002020
Language:
English
Keywords:
Pubs id:
1177899
Local pid:
pubs:1177899
Deposit date:
2022-11-23

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