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Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels

Abstract:

Protein–lipid interactions are a key element of the function of many integral membrane proteins. These potential interactions should be considered alongside the complexity and diversity of membrane lipid composition. Inward rectifier potassium channel (Kir) Kir2.2 has multiple interactions with plasma membrane lipids: Phosphatidylinositol (4, 5)-bisphosphate (PIP2) activates the channel; a secondary anionic lipid site has been identified, which augments the activation by PIP2; and cholesterol...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1918387117

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0001-6360-7959
More from this funder
Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/L002558/1
BB/R00126X/1
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Name:
Wellcome Trust
Grant:
208361/Z/17/Z
More from this funder
Name:
Engineering & Physical Sciences Research Council
Grant:
EP/J010421/1
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
117
Issue:
14
Pages:
7803-7813
Publication date:
2020-03-25
Acceptance date:
2020-03-02
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
1090744
Local pid:
pubs:1090744
Deposit date:
2020-03-03

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