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Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.

Abstract:

ATP-sensitive potassium (KATP) channels are reversibly inhibited by intracellular ATP. Agents that interact with sulfhydryl moieties produce an irreversible inhibition of KATP channel activity when applied to the intracellular membrane surface. ATP appears to protect against this effect, suggesting that the cysteine residue with which thiol reagents interact may either lie within the ATP-binding site or be inaccessible when the channel is closed. We have examined the interaction of the membra...

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Publication status:
Published

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Publisher copy:
10.1085/jgp.112.3.325

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
The Journal of general physiology
Volume:
112
Issue:
3
Pages:
325-332
Publication date:
1998-09-05
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:46d80238-ee8d-49d4-bbc2-e927f85ab216
Source identifiers:
29682
Local pid:
pubs:29682

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