Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis.

Journal article

BACKGROUND: In the majority of people with familial hypercholesterolaemia (FH) the disorder is caused by a mutation of the low-density lipoprotein receptor gene that impairs its proper function, resulting in very high levels of plasma cholesterol. Such levels result in early and severe atherosclerosis, and hence substantial excess mortality from coronary heart disease. Most people with FH are undiagnosed or only diagnosed after their first coronary event, but early detection and treatment wit...

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Authors: Marks, D; Wonderling, D; Thorogood, M; Lambert, H; Humphries, SE

• Journal: Health technology assessment (Winchester, England)
• Volume: 4
• Issue: 29
• Pages: 1-123
• Publication date: 2000-01-01
• EISSN: 2046-4924
• ISSN: 1366-5278
• Language: English
• Keywords: Child; Technology Assessment, Biomedical; Morbidity; Attitude to Health; Needs Assessment; Great Britain; Hyperlipoproteinemia Type II; Decision Trees; Research Design; Female; Male; Mass Screening; Algorithms; Adult; Aged; Cost-Benefit Analysis; Practice Guidelines as Topic; Models, Econometric; Middle Aged; Humans