Characterization of the HLA-A2.2 subtype: T cell evidence for further heterogeneity.

Journal article

Five blood donors were identified whose HLA-A2 is different from the common HLA-A2. Their A2 molecule (A2.2) had a more basic isoelectric point than normal A2 (A2.1). Cytotoxic T lymphocytes (CTL) restricted by HLA-A2.1, specific for influenza A and Epstein-Barr viruses, failed to lyse virus-infected target cells with HLA-A2.2. Identical patterns were obtained with both viruses. CTL from four of the A2.2-positive donors recognized target cells prepared from others in the group that shared onl...

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Authors: Gotch, F; Kelly, C; Ellis, SA; Wallace, L; Rickinson, AB

• Publication status: Published
• Publisher: Springer-Verlag
• Journal: Immunogenetics
• Volume: 21
• Issue: 1
• Pages: 11-23
• Publication date: 1985-01-01
• DOI: 10.1007/bf00372237
• EISSN: 1432-1211
• ISSN: 0093-7711
• Language: English
• Keywords: Genetic Variation; Isoelectric Point; Humans; HLA-A2 Antigen; Herpesvirus 4, Human; HLA Antigens; Influenza A virus; Peptides; T-Lymphocytes, Cytotoxic; Cytotoxicity, Immunologic