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Characterization of the HLA-A2.2 subtype: T cell evidence for further heterogeneity.

Abstract:

Five blood donors were identified whose HLA-A2 is different from the common HLA-A2. Their A2 molecule (A2.2) had a more basic isoelectric point than normal A2 (A2.1). Cytotoxic T lymphocytes (CTL) restricted by HLA-A2.1, specific for influenza A and Epstein-Barr viruses, failed to lyse virus-infected target cells with HLA-A2.2. Identical patterns were obtained with both viruses. CTL from four of the A2.2-positive donors recognized target cells prepared from others in the group that shared onl...

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Publication status:
Published

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Publisher copy:
10.1007/bf00372237

Authors


Wallace, L More by this author
Rickinson, AB More by this author
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Publisher:
Springer-Verlag
Journal:
Immunogenetics
Volume:
21
Issue:
1
Pages:
11-23
Publication date:
1985
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:46ce5a89-e197-4dbc-a2fc-072bf92ba8d3
Source identifiers:
42405
Local pid:
pubs:42405

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