- Abstract:
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Ischaemia and reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI), which contributes to high morbidity and mortality rates in a wide range of injuries as well as the development of chronic kidney disease. The cellular and molecular responses of the kidney to IRI are complex and not fully understood. Here, we used an integrated proteomic and metabolomic approach to investigate the effects of IRI on protein abundance and metabolite levels. Rat kidneys were subjected to 45...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.5MB)
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- Publisher copy:
- 10.1038/s41598-018-26804-8
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- Publisher:
- Nature Publishing Group: Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 8
- Pages:
- Article: 8539
- Publication date:
- 2018-06-04
- Acceptance date:
- 2018-05-18
- DOI:
- ISSN:
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2045-2322
- Pubs id:
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pubs:855750
- URN:
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uri:46bf3314-e2a1-4481-a2fb-cb7620e766f8
- UUID:
-
uuid:46bf3314-e2a1-4481-a2fb-cb7620e766f8
- Local pid:
- pubs:855750
- Copyright holder:
- © Huang, et al
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion
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