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Proteo-metabolomics reveals compensation between ischemic and non-injured contralateral kidneys after reperfusion

Abstract:

Ischaemia and reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI), which contributes to high morbidity and mortality rates in a wide range of injuries as well as the development of chronic kidney disease. The cellular and molecular responses of the kidney to IRI are complex and not fully understood. Here, we used an integrated proteomic and metabolomic approach to investigate the effects of IRI on protein abundance and metabolite levels. Rat kidneys were subjected to 45...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-018-26804-8

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
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Funding agency for:
Ploeg, RJ
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Funding agency for:
Kessler, BM
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Funding agency for:
Kessler, BM
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Publisher:
Nature Publishing Group: Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Pages:
Article: 8539
Publication date:
2018-06-04
Acceptance date:
2018-05-18
DOI:
ISSN:
2045-2322
Pubs id:
pubs:855750
URN:
uri:46bf3314-e2a1-4481-a2fb-cb7620e766f8
UUID:
uuid:46bf3314-e2a1-4481-a2fb-cb7620e766f8
Local pid:
pubs:855750

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