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Journal article

Evaluation of complexes of DNA duplexes and novel benzoxazoles or benzimidazoles by electrospray ionization mass spectrometry.

Abstract:

Electrospray ionization mass spectrometry is used to compare the metal ion binding and metal-mediated DNA binding of benzoxazole (1, 2, 3, 4) and benzimidazole (5) compounds and to elucidate the putative binding modes and stoichiometries. The observed metal versus non-metal-mediated DNA binding, as well as the specificity of DNA binding, is correlated with the biological activities of the analogs. The ESI-MS spectra for the antibacterial benzoxazole and benzimidazole analogs 4 and 5 demonstra...

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Publication status:
Published

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Publisher copy:
10.1016/j.jasms.2004.07.015

Authors


Journal:
Journal of the American Society for Mass Spectrometry
Volume:
15
Issue:
11
Pages:
1593-1603
Publication date:
2004-11-01
DOI:
EISSN:
1879-1123
ISSN:
1044-0305
Source identifiers:
182135
Language:
English
Keywords:
Pubs id:
pubs:182135
UUID:
uuid:46b5c69c-6b65-4c45-8d2c-83daeddd7246
Local pid:
pubs:182135
Deposit date:
2012-12-19

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