Journal article icon

Journal article

The pharmacological profile of a novel highly potent bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)

Abstract:

Bisphosphonates are widely used in the treatment of clinical disorders characterized by increased bone resorption, including osteoporosis, Paget's disease, and the skeletal complications of malignancy. The antiresorptive potency of the nitrogen-containing bisphosphonates on bone in vivo is now recognized to depend upon two key properties, namely mineral binding affinity and inhibitory activity on farnesyl pyrophosphate synthase (FPPS), and these properties vary independently of each other in ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1002/jbmr.3138

Authors


More by this author
Role:
Author
ORCID:
0000-0002-5446-923X
Procter and Gamble More from this funder
Publisher:
American Society for Bone and Mineral Research Publisher's website
Journal:
Journal of Bone and Mineral Research Journal website
Volume:
32
Issue:
9
Pages:
1860-1869
Publication date:
2017-04-21
Acceptance date:
2017-03-22
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
Pmid:
28337806
Language:
English
Keywords:
Pubs id:
pubs:687171
UUID:
uuid:46b10779-0dbb-4f67-82b8-cbbf6607dce3
Local pid:
pubs:687171
Source identifiers:
687171
Deposit date:
2017-12-06

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP