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The pharmacological profile of a novel highly potent bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)

Abstract:

Bisphosphonates are widely used in the treatment of clinical disorders characterized by increased bone resorption, including osteoporosis, Paget's disease, and the skeletal complications of malignancy. The antiresorptive potency of the nitrogen-containing bisphosphonates on bone in vivo is now recognized to depend upon two key properties, namely mineral binding affinity and inhibitory activity on farnesyl pyrophosphate synthase (FPPS), and these properties vary independently of each other in ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/jbmr.3138

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ORCID:
0000-0002-5446-923X
Ebetino, FH More by this author
Chantry, AD More by this author
Paton-Hough, J More by this author
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Procter and Gamble More from this funder
Publisher:
American Society for Bone and Mineral Research Publisher's website
Journal:
Journal of Bone and Mineral Research Journal website
Volume:
32
Issue:
9
Pages:
1860-1869
Publication date:
2017-04-21
Acceptance date:
2017-03-22
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
Pubs id:
pubs:687171
URN:
uri:46b10779-0dbb-4f67-82b8-cbbf6607dce3
UUID:
uuid:46b10779-0dbb-4f67-82b8-cbbf6607dce3
Local pid:
pubs:687171
Paper number:
9

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