- Abstract:
-
Bisphosphonates are widely used in the treatment of clinical disorders characterized by increased bone resorption, including osteoporosis, Paget's disease, and the skeletal complications of malignancy. The antiresorptive potency of the nitrogen-containing bisphosphonates on bone in vivo is now recognized to depend upon two key properties, namely mineral binding affinity and inhibitory activity on farnesyl pyrophosphate synthase (FPPS), and these properties vary independently of each other in ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.2mb)
-
- Publisher copy:
- 10.1002/jbmr.3138
-
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- Publisher:
- American Society for Bone and Mineral Research Publisher's website
- Journal:
- Journal of Bone and Mineral Research Journal website
- Volume:
- 32
- Issue:
- 9
- Pages:
- 1860-1869
- Publication date:
- 2017-04-21
- Acceptance date:
- 2017-03-22
- DOI:
- EISSN:
-
1523-4681
- ISSN:
-
0884-0431
- Pubs id:
-
pubs:687171
- URN:
-
uri:46b10779-0dbb-4f67-82b8-cbbf6607dce3
- UUID:
-
uuid:46b10779-0dbb-4f67-82b8-cbbf6607dce3
- Local pid:
- pubs:687171
- Paper number:
- 9
- Language:
- English
- Keywords:
- Copyright holder:
- © 2017 Lawson, et al
- Copyright date:
- 2017
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Journal article
The pharmacological profile of a novel highly potent bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)
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Procter and Gamble
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