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Journal article

Biological exacerbation clusters demonstrate asthma and COPD overlap with distinct mediator and microbiome profiles

Abstract:

Background

Exacerbations of asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous.

Objective

We sought to investigate the sputum cellular, mediator, and microbiome profiles of both asthma and COPD exacerbations.

Methods

Patients with severe asthma or moderate-to-severe COPD were prospectively recruited to a single centre. Sputum mediators were available in 32 asthma and 73 COPD patients assessed at exacerbation. Biologic clusters were det...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jaci.2018.04.013

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0002-9993-2478
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MedImmune Ltd More from this funder
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Grant:
Senior Fellowship
European Regional Development Fund More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Journal of Allergy and Clinical Immunology Journal website
Volume:
141
Issue:
6
Pages:
2027-2036.e12
Publication date:
2018-04-27
Acceptance date:
2018-04-24
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
Pmid:
29709671
Source identifiers:
846155
Language:
English
Keywords:
Pubs id:
pubs:846155
UUID:
uuid:46b0c1a1-dbef-47aa-ad94-4c7dd54532e6
Local pid:
pubs:846155
Deposit date:
2018-05-09

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