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Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.

Abstract:

The initiation and progression of breast cancer from the transformation of the normal epithelium to ductal carcinoma in situ (DCIS) and invasive disease is a complex process involving the acquisition of genetic alterations and changes in gene expression, alongside microenvironmental and recognized histological alterations. Here, we sought to comprehensively characterise the genomic and transcriptomic features of the MCF10 isogenic model of breast cancer progression, and to functionally valida...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/path.4778

Authors


Maguire, SL More by this author
Campbell, J More by this author
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Breast Cancer Now More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
240
Issue:
3
Pages:
315-328
Publication date:
2016-08-05
Acceptance date:
2016-08-02
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Pubs id:
pubs:638667
URN:
uri:46acf882-fe24-4d0f-8a7a-e5f94a700cac
UUID:
uuid:46acf882-fe24-4d0f-8a7a-e5f94a700cac
Local pid:
pubs:638667

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