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Multiway Admixture Deconvolution Using Phased or Unphased Ancestral Panels

Abstract:

We describe a novel method for inferring the local ancestry of admixed individuals from dense genome-wide single nucleotide polymorphism data. The method, called MULTIMIX, allows multiple source populations, models population linkage disequilibrium between markers and is applicable to datasets in which the sample and source populations are either phased or unphased. The model is based upon a hidden Markov model of switches in ancestry between consecutive windows of loci. We model the observed...

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Publisher copy:
10.1002/gepi.21692

Authors


Churchhouse, C More by this author
Marchini, J More by this author
Journal:
Genetic Epidemiology
Volume:
37
Issue:
1
Pages:
1-12
Publication date:
2013-01-05
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
URN:
uuid:469da11b-01c5-41c0-b610-475c673cb18d
Source identifiers:
371442
Local pid:
pubs:371442
Language:
English
Keywords:

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