Intravenous iron supplementation may protect against acute mountain sickness: a randomized, double-blinded, placebo-controlled trial.

Journal article

Acute mountain sickness (AMS) is a common and disabling condition that occurs in healthy individuals ascending to high altitude. Based on the ability of iron to influence cellular oxygen sensing pathways, we hypothesized that iron supplementation would protect against AMS. To examine this hypothesis, 24 healthy sea-level residents were randomized to receive either intravenous iron(III)-hydroxide sucrose (200 mg) or saline placebo, before ascending rapidly to Cerro de Pasco, Peru (4340 m). The...

Expand abstract

Authors: Talbot, N; Smith, T; Privat, C; Nickol, A; Rivera-Ch, M

• Publication status: Published
• Journal: High altitude medicine and biology
• Volume: 12
• Issue: 3
• Pages: 265-269
• Publication date: 2011-01-01
• DOI: 10.1089/ham.2011.1005
• EISSN: 1557-8682
• ISSN: 1527-0297
• Language: English
• Keywords: Sucrose; Hematocrit; Adult; Ferritins; Injections, Intravenous; Male; Oxygen; Acute Disease; Altitude Sickness; Young Adult; Ferric Compounds; Humans; Severity of Illness Index