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PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications.

Abstract:

Deubiquitinating enzymes (DUBs) constitute a diverse protein family and their impact on numerous biological and pathological processes has now been widely appreciated. Many DUB functions have to be tightly controlled within the cell, and this can be achieved in several ways, such as substrate-induced conformational changes, binding to adaptor proteins, proteolytic cleavage, and post-translational modifications (PTMs). This review is focused on the role of PTMs including monoubiquitination, su...

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Publication status:
Published

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Publisher copy:
10.1007/s12013-011-9176-6

Authors


Kessler, BM More by this author
Edelmann, MJ More by this author
Journal:
Cell biochemistry and biophysics
Volume:
60
Issue:
1-2
Pages:
21-38
Publication date:
2011-06-05
DOI:
EISSN:
1559-0283
ISSN:
1085-9195
URN:
uuid:468e1626-0ed1-4f5a-9db6-4c41c300d46e
Source identifiers:
131052
Local pid:
pubs:131052

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