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The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity.

Abstract:

Arterial and venous specification is critical for establishing and maintaining a functioning vascular system, and defects in key arteriovenous signaling pathways including VEGF (vascular endothelial growth factor) lead to congenital arteriopathies. The activities of VEGF, are in part controlled by heparan sulfate (HS) proteoglycans, significant components of the endothelial glycocalyx. The level of 6-O sulfation on HS polysaccharide chains, that mediate the interaction between HS and VEGFA, i...

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Publication status:
Published

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Publisher copy:
10.1007/s10456-013-9379-0

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Journal:
Angiogenesis
Volume:
17
Issue:
1
Pages:
77-91
Publication date:
2014-01-05
DOI:
EISSN:
1573-7209
ISSN:
0969-6970
URN:
uuid:468aefce-1d23-408f-ac95-77c1dd20eeb0
Source identifiers:
418560
Local pid:
pubs:418560

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