Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making.

Journal article

Both the anterior cingulate cortex (ACC) and mesolimbic dopamine, particularly in the nucleus accumbens (NAc), have been implicated in allowing an animal to overcome effort constraints to obtain greater benefits. However, their exact contribution to such decisions has, to date, never been directly compared. To investigate this issue we tested rats on an operant effort-related cost-benefit decision-making task where animals selected between two response alternatives, one of which involved inve...

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Authors: Walton, M; Groves, J; Jennings, K; Croxson, P; Sharp, T

• Publication status: Published
• Journal: European journal of neuroscience
• Volume: 29
• Issue: 8
• Pages: 1678-1691
• Publication date: 2009-04-01
• DOI: 10.1111/j.1460-9568.2009.06726.x
• EISSN: 1460-9568
• ISSN: 0953-816X
• Language: English
• Keywords: Dopamine Antagonists; Gyrus Cinguli; Neuropsychological Tests; Receptors, Dopamine D2; Male; Decision Making; Haloperidol; Adrenergic Agents; Dopamine; Rats; Oxidopamine; Conditioning, Operant; Nucleus Accumbens; Behavior, Animal; Animals