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Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making.

Abstract:

Both the anterior cingulate cortex (ACC) and mesolimbic dopamine, particularly in the nucleus accumbens (NAc), have been implicated in allowing an animal to overcome effort constraints to obtain greater benefits. However, their exact contribution to such decisions has, to date, never been directly compared. To investigate this issue we tested rats on an operant effort-related cost-benefit decision-making task where animals selected between two response alternatives, one of which involved inve...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Journal:
European journal of neuroscience
Volume:
29
Issue:
8
Pages:
1678-1691
Publication date:
2009-04-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Source identifiers:
30352
Language:
English
Keywords:
Pubs id:
pubs:30352
UUID:
uuid:4681cacd-ba4e-4cf9-9cdc-0fbaea2c97d5
Local pid:
pubs:30352
Deposit date:
2012-12-19

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