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A study of the factors affecting the metabolic clearance of quinine in malaria.

Abstract:

OBJECTIVE: To assess the factors that contribute to impaired quinine clearance in acute falciparum malaria. PATIENTS: Sixteen adult Thai patients with severe or moderately severe falciparum malaria were studied, and 12 were re-studied during convalescence. METHODS: The clearance of quinine, dihydroquinine (an impurity comprising up to 10% of commercial quinine formulations), antipyrine (a measure of hepatic mixed-function oxidase activity), indocyanine green (ICG) (a measure of liver blood fl...

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Publication status:
Published

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Publisher copy:
10.1007/s002280050323

Authors


Pukrittayakamee, S More by this author
Looareesuwan, S More by this author
Keeratithakul, D More by this author
Teja-Isavadharm, P More by this author
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Journal:
European journal of clinical pharmacology
Volume:
52
Issue:
6
Pages:
487-493
Publication date:
1997
DOI:
EISSN:
1432-1041
ISSN:
0031-6970
URN:
uuid:4681942f-cb0f-418f-9b6a-4b789bd253b2
Source identifiers:
231
Local pid:
pubs:231

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