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Inhibition of ATP-regulated K(+)-channels by a photoactivatable ATP-analogue in mouse pancreatic beta-cells.

Abstract:

The effects of a photoactivable (DMNPE-caged) ATP-analogue on ATP-regulated K(+)-channels (KATP-channel) in mouse pancreatic beta-cells were investigated using the inside-out patch configuration of the patch-clamp technique. The caged precursor caused a concentration-dependent reduction of channel activity with a Ki of 17 microM; similar to the 11 microM obtained for standard Mg-ATP. The small difference in the blocking capacity between the precursor and ATP is probably the reason why no chan...

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Publication status:
Published

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Authors


Ammälä, C More by this author
Bokvist, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Biochimica et biophysica acta
Volume:
1092
Issue:
3
Pages:
347-349
Publication date:
1991-05-05
DOI:
ISSN:
0006-3002
URN:
uuid:46551143-dba3-4010-bdff-706ba85c3fad
Source identifiers:
19774
Local pid:
pubs:19774

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