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ATPase site architecture and helicase mechanism of an archaeal MCM

Abstract:

The subunits of the presumptive replicative helicase of archaea and eukaryotes, the MCM complex, are members of the AAA+ (ATPase-associated with various cellular activities) family of ATPases. Proteins within this family harness the chemical energy of ATP hydrolysis to perform a broad range of cellular processes. Here, we investigate the function of the AAA+ site in the mini-chromosome maintenance (MCM) complex of the archaeon Sulfolobus solfataricus (SsoMCM). We find that SsoMCM has...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
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Institution:
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
More by this author
Institution:
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
More by this author
Institution:
MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
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Institution:
University of Oxford
Department:
Medical Sciences Division - Pathology
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Funding agency for:
Laura S. Itzhaki
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Funding agency for:
Stephen D. Bell
Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
28
Issue:
2
Pages:
304-314
Publication date:
2007-10-05
DOI:
URN:
uuid:4634ff8f-5355-4133-b5a8-766f1f726389
Local pid:
ora:5586
Language:
English
Subjects:

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