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Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria.

Abstract:

Pregnant women are particularly vulnerable to malaria. The pharmacokinetic properties of antimalarial drugs are often affected by pregnancy, resulting in lower drug concentrations and a consequently higher risk of treatment failure. The objective of this study was to evaluate the population pharmacokinetic properties of piperaquine and dihydroartemisinin in pregnant and nonpregnant women with uncomplicated malaria. Twenty-four pregnant and 24 matched nonpregnant women on the Thai-Myanmar boar...

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Publication status:
Published

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Publisher copy:
10.1128/aac.05756-11

Authors


Tarning, J More by this author
Rijken, MJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Hanpithakpong, W More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
56
Issue:
4
Pages:
1997-2007
Publication date:
2012-04-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:462eff97-9406-4170-98a2-bdab6f388e17
Source identifiers:
237567
Local pid:
pubs:237567

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