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Connective tissue remodeling: cross-talk between endothelins and matrix metalloproteinases.

Abstract:

Connective tissue remodeling is achieved by a complex process involving several cell types, a plethora of growth factors, cytokines, chemokines and turnover of extracellular matrix (ECM). The main enzymes that degrade ECM molecules are matrix metalloproteinases (MMPs) and their activities are regulated by endogenous inhibitors, the tissue inhibitors of metalloproteinases (TIMPs). Recent studies have indicated that endothelins and their receptor expression affects tissue remodeling and repair....

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Publisher copy:
10.2174/157016105774329480

Authors


Abraham, D More by this author
Ponticos, M More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Current vascular pharmacology
Volume:
3
Issue:
4
Pages:
369-379
Publication date:
2005-10-05
DOI:
EISSN:
1875-6212
ISSN:
1570-1611
URN:
uuid:46264973-51c0-4326-874d-4a39534804e3
Source identifiers:
227432
Local pid:
pubs:227432

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