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Glial activation in the early stages of brain metastasis: TSPO as a diagnostic biomarker.

Abstract:

UNLABELLED: Metastatic spread of cancer cells to the brain is associated with high mortality, primarily because current diagnostic tools identify only well-advanced metastases. Brain metastases have been shown to induce a robust glial response, including both astrocyte and microglial activation. On the basis of these findings, we hypothesized that this stromal response may provide a sensitive biomarker of tumor burden, in particular through the use of SPECT/PET imaging agents targeting the tr...

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Publication status:
Published

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Publisher copy:
10.2967/jnumed.113.127449

Authors


O'Brien, ER More by this author
Kersemans, V More by this author
Tredwell, M More by this author
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Publisher:
Society of Nuclear Medicine Inc.
Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume:
55
Issue:
2
Pages:
275-280
Publication date:
2014-02-05
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:4604a24c-a38b-4194-9aaa-eb59ba9adfaa
Source identifiers:
446610
Local pid:
pubs:446610

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