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Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload

Abstract:
Objective To assess pharmacokinetics and changes to sodium levels in addition to adverse events (AEs) associated with fosfomycin among neonates with clinical sepsis.
Design A single-centre open-label randomised controlled trial.
Setting Kilifi County Hospital, Kenya.
Patients 120 neonates aged ≤28 days admitted being treated with standard-of-care (SOC) antibiotics for sepsis: ampicillin and gentamicin between M... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1136/archdischild-2021-322483

Authors


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Role:
Author
ORCID:
0000-0002-9321-0183

Contributors

Role:
Contributor
Publisher:
BMJ Publishing Group
Journal:
Archives of Disease in Childhood More from this journal
Volume:
107
Issue:
9
Pages:
802-810
Publication date:
2022-01-25
Acceptance date:
2021-12-24
DOI:
EISSN:
1468-2044
ISSN:
0003-9888
Language:
English
Keywords:
Pubs id:
1234381
Local pid:
pubs:1234381
Deposit date:
2022-01-27

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