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Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells

Abstract:

Ataxia telangiectasia (A-T) is a syndrome associated with loss of ATM protein function. Neurodegeneration and cancer predisposition, both hallmarks of A-T, are likely to emerge as a consequence of the persistent oxidative stress and DNA damage observed in this disease. Surprisingly however, despite these severe features, a lack of functional ATM is still compatible with early life, suggesting that adaptation mechanisms contributing to cell survival must be in place. Here we address this gap i...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkx635

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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, Oncology
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Department:
Oxford, MSD, NDM, Target Discovery Institute
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
45
Issue:
17
Pages:
10042–10055
Publication date:
2017-07-24
Acceptance date:
2017-07-20
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pubs id:
pubs:724556
URN:
uri:45fb7ae8-40e6-4c0f-a8ec-ce3402986ce4
UUID:
uuid:45fb7ae8-40e6-4c0f-a8ec-ce3402986ce4
Local pid:
pubs:724556

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