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Journal article

Functional characterization of the cloned human ACTH receptor: impaired responsiveness of a mutant receptor in familial glucocorticoid deficiency.

Abstract:

The putative ACTH receptor gene has been identified on the basis of its tissue specific expression, structure, and limited expression data. We have expressed this gene in COS-7 cells and measured cAMP production in response to ACTH. An EC50 of 5.5 x 10(-9) M for ACTH (1-24) was determined. The S74I mutant ACTH receptor gene that associates with the syndrome of familial glucocorticoid deficiency had an EC50 of 67 x 10(-9) M. This discrepancy is consistent with the clinical data, and supports t...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.1993.2456

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
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Journal:
Biochemical and biophysical research communications
Volume:
197
Issue:
1
Pages:
172-178
Publication date:
1993-11-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:45ecb09b-2516-43a6-8d84-421095af9abf
Source identifiers:
138147
Local pid:
pubs:138147

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