- Abstract:
-
The putative ACTH receptor gene has been identified on the basis of its tissue specific expression, structure, and limited expression data. We have expressed this gene in COS-7 cells and measured cAMP production in response to ACTH. An EC50 of 5.5 x 10(-9) M for ACTH (1-24) was determined. The S74I mutant ACTH receptor gene that associates with the syndrome of familial glucocorticoid deficiency had an EC50 of 67 x 10(-9) M. This discrepancy is consistent with the clinical data, and supports t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1006/bbrc.1993.2456
-
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- Journal:
- Biochemical and biophysical research communications
- Volume:
- 197
- Issue:
- 1
- Pages:
- 172-178
- Publication date:
- 1993-11-05
- DOI:
- EISSN:
-
1090-2104
- ISSN:
-
0006-291X
- URN:
-
uuid:45ecb09b-2516-43a6-8d84-421095af9abf
- Source identifiers:
-
138147
- Local pid:
- pubs:138147
- Copyright date:
- 1993
Journal article
Functional characterization of the cloned human ACTH receptor: impaired responsiveness of a mutant receptor in familial glucocorticoid deficiency.
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