Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns.

Katulanda, G; Katulanda, P; Adler, A; Peiris, SR; Draisey, I; Wijeratne, S; Sheriff, R; Matthews, DR; Shine, B

Journal article

Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns.

Abstract:: BACKGROUND: Apolipoproteins B (apoB) and AI (apoAI) are strong predictors of cardiovascular disease (CVD). We describe apolipoprotein distributions and their associations with lipids and diabetes subtype in diabetic young adult South Asians. METHODS: In 995 subjects with diabetes, we measured fasting total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), triglycerides (TG), apoB and apoAI, glycosylated haemoglobin (HbA1c) and glutamic acid decarboxylase antibodies (GADA). Low-density lipoprotein cholesterol (LDLC) and non-HDLC (NHDLC) were calculated. We compared values in subjects aged 15-50 y from the United States National Health and Nutrition Examination Survey (NHANES). RESULTS: Median age and duration of diabetes were 38 (range 14-45) and 4 (0-24) y. Men had significantly higher TC, TG, NHDLC, TC/HDLC, apoB/AI and NHDLC/apoB, and lower apoAI than women. Compared with the reference group, patients with type 1 diabetes had lower TG, apoB:apoAI and HDLC:apoAI, and higher HDLC and apoAI. Patients with type 2 diabetes had higher TG, TC, LDLC, NHDLC, TC:HDL, apoB, apoAI and apoB:apoAI, and lower HDLC, LDLC:apoB and HDLC:apoAI. Among patients with type 2 diabetes, 54% had high apoB (>1.2 g/L) and 33% also had high TG (>1.5 mmol/L). Measures of obesity (body mass index and waist circumference) were weakly correlated with lipid and apoprotein parameters, suggesting a modest contribution to dyslipidaemia. CONCLUSIONS: A large proportion of young adult Sri Lankan patients with type 2 diabetes has a low LDLC:apoB and high apoB and/or TG, suggesting that these patients are at increased risk of CVD.

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APA Style

Katulanda, G., Katulanda, P., Adler, A., Peiris, S. R., Draisey, I., Wijeratne, S., Sheriff, R., Matthews, D. R., & Shine, B. (2010). Apolipoproteins in diabetes dyslipidaemia in South Asians with young adult-onset diabetes: distribution, associations and patterns. Annals of Clinical Biochemistry, 47(Pt 1), 29–34.

MLA Style

Katulanda, G., et al. “Apolipoproteins in Diabetes Dyslipidaemia in South Asians with Young Adult-Onset Diabetes: Distribution, Associations and Patterns.” Annals of Clinical Biochemistry, vol. 47, no. Pt 1, 2010, pp. 29–34.

Chicago Style

Katulanda, G, P Katulanda, A Adler, SR Peiris, I Draisey, S Wijeratne, R Sheriff, DR Matthews, and B Shine. 2010. “Apolipoproteins in Diabetes Dyslipidaemia in South Asians with Young Adult-Onset Diabetes: Distribution, Associations and Patterns.” Annals of Clinical Biochemistry 47 (Pt 1): 29–34.
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