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Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines.

Abstract:

CD8(+) T cell-numbers rapidly expand and then contract after exposure to their cognate antigen. Here we show that the sustained frequencies of transgene product-specific CD8(+) T cells elicited by replication-defective adenovirus vectors are linked to persistence of low levels of transcriptionally active adenovirus vector genomes at the site of inoculation, in liver, and lymphatic tissues. Continuously produced small amounts of antigen maintain fully active effector CD8(+) T cells, while also...

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Publication status:
Published

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Authors


Fitzgerald, JC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Harris-McCoy, KC More by this author
Hensley, SE More by this author
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Journal:
Blood
Volume:
110
Issue:
6
Pages:
1916-1923
Publication date:
2007-09-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:45df700e-659e-4f7d-b34e-56449c96e104
Source identifiers:
103590
Local pid:
pubs:103590

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